NAC, Cys and 3MP trigger the generation of H 2 S and persulfides The working hypothesis (Figure 1E) predicted that NAC, Cys and 3MP treatments trigger endogenous H 2 S production
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Oral glutathione has significantly lower bioavailability because it is partially broken down during digestion
For patients without established ASCVD, indicators of high ASCVD risk, CKD, or heart failure, the choice of a second agent is based on avoidance of side effects, particularly hypoglycemia and weight gain
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