If you're considering the semaglutide weight loss path, favorable candidates have a BMI of 30+ or 27+ with related health issues like high blood pressure or type 2 diabetes
Men in the same groups lost 19.8 percent and 21.9 percent
Conversely, mice defective for both the receptors for glucagon and GLP-1, or GLP-1 and GIP, show a highly plastic entero-pancreatic system that adapts and gives these animals no overt phenotype in terms of glucose homeostasis (105)
Vinicius Cruzat, Marcelo Macedo Rogero, Kevin Noel Keane, Rui Curi, Philip Newsholme (2018 Oct) Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation
Sanjai Sinha, MD Medical Reviewer Veronica Johnson, MD, FAAP, FACP, Dipl