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For example, remicade, a clinically used anti-TNF- antibody targeting the p50 and p65 NF-B subtype of small interfering RNA and curcumin, a well-characterized natural NF-B inhibitor that is also a dominant negative inhibitor of B (IB), can inhibit GGT activation through distinct mechanisms

[2] [3] According to the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), gastrointestinal disturbances affect a substantial proportion of patients , particularly during the initial weeks of treatment or following dose escalation