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Studies have demonstrated that microneedle-mediated administration of tacrolimus, tofacitinib, or -MSH achieves superior repigmentation compared to conventional topical or systemic routes, while reducing systemic exposure and associated risks like immunosuppression (141)

Moreover, miRNAs are also involved in intercellular communication, with keratinocyte-derived exosomal miR-203 and miR-3196 influencing melanogenesis, and melanocyte-derived exosomal miRNAs participating in stress response and potentially melanoma initiation 104,106

Specifically, we observed a stacked, filament-like architecture in which only WD40 domains of COP1 in the top layer are accessible, and a substrate-accessible dimeric architecture that is favored upon co-expression of c-Jun or ETS2

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