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In the US, it is primarily used for the treatment of postmenopausal women with osteoporosis at high risk of fracture and for treatment to increase bone mass in men with osteoporosis at high risk of fracture

The 2023 international evidence-based PCOS guideline positions lifestyle modification as foundational for all women, recommends metformin for metabolic features (especially at higher BMI), notes limited benefit for inositol, and importantly recognizes that anti-obesity medications, including GLP-1-based agents, can be considered for weight management in PCOS while emphasizing that evidence in this population remains limited and largely off-label

GLP-1 medications help people feel fuller sooner and stay fuller longer by slowing gastric emptying and modulating appetite signals in the brain

For instance, lower levels may play a role in many conditions that are more likely to develop in older people