doi: 10.1016/j.cell.2020.02.042 36
doi: 10.1002/ps.5452 Monk, Ian R., Shaikh, Nausad, Begg, Stephanie L., Gajdiss, Mike, Sharkey, Liam K
Key study identifying the contribution of ceramide to glucocorticoid-induced insulin resistance, which highlights the potential of targeting ceramide pharmacologically to eliminate glucocorticoid-dependent disruption in glucose homeostasis
Neuron 74:858873 Wauquier A, Rolls ET (1976) Brain-stimulation reward
That modification is the key engineering trick: it makes the molecule more resistant to the enzymes that would normally break GHRH down quickly, giving tesamorelin a longer working window than sermorelin while still acting on the same GHRH receptor