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Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jodar E, Leiter LA, et al

Expression of a specific VEGF isoform in an otherwise non-tumorigenic, non-VEGF expressing melanoma cell line results in an aggressive tumor with a highly extensive supporting vasculature, suggesting its undisputed role in promoting angiogenesis (88)

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Local anesthetics such as lidocaine have been found to preserve NK cell function, reduce surgery-related sympathetic stress responses and decrease systemic opioid requirements [24]