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Stronger Side Effects: The rapid delivery of a larger dose can result in more noticeable side effects, such as nausea, diarrhea, and constipation

According to UK guidance, metformin is contraindicated in patients with eGFR below 30 mL/min/1.73m, should not be initiated in those with eGFR 30-44 mL/min/1.73m, and requires dose review/reduction for eGFR 30-59 mL/min/1.73m

Finally, the perspectives regarding investigating the role of Se and selenoproteins in the gut-brain axis are outlined

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