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The residual compound load is higher, and GI sensitivity tends to increase with longer tirzepatide exposure at these doses

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constructed a novel GLP-1/fibroblast growth factor (FGF)-21 dual receptor agonist (GLP-1-Fc-FGF21 D1), which was evaluated in HFD ob/ob mice in comparison with either FGF-21 (c-FGF21 S1) or GLP-1RA (dulaglutide) monotherapy