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Restoration of DJ-1 expression ameliorates these defects by enhancing mitochondrial electron transport chain activity and reducing ROS overproduction, thereby attenuating oxidative stress-mediated neuronal damage (McCoy and Cookson, 2011)

GLP- 1 receptor activation has longer-term consequences, such as increased b cell proliferation and neogenesis along with cytoprotective (non-insulinotropic) effects [45,46,47,48,49,50,51]

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Despite advances in our molecular understanding, management challenges remain