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Yuan XH, Jin ZH

Proteasome inhibition results in stabilization of several key tumor suppressing proteins (e.g., NFKB inhibitor alpha [NFKBIA/IKBA] ( Targeting DUBs: A Novel Strategy for Cancer Therapy DUBs can be divided into six families based on their different structures: ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs), ovarian-tumor proteases (OTUs), JAMM/MPN domainassociated metallopeptidases (JAMMs), MachadoJoseph disease protein domain proteases (MJD), and monocyte chemotactic protein-induced protein (MCPIP) (Yao and Cohen, 2002)

Staying too low may limit therapeutic benefit

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Protocol changes (dose reduction, timing changes) should be used before resuming