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154 The relatively low mechanical stress (about 45 Pa) derived by the ECM can stimulate the stem cell signaling pathway via the cytoskeleton/AIRE axis by activating the integrin beta 1/3 receptor, while excessive mechanical stress (~450 Pa) induces quiescence in BCSCs dependent on DDR2/STAT1/P27 signaling, which may explain conflicting results observed in previous individual studies

doi: 10.1016/j.coi.2009.03.001 28 LangrishCLChenYBlumenscheinWMMattsonJBashamBSedgwickJDet al

doi: 10.1038/srep09114, 126