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Tesamorelins visceral-fat effect rests on randomized, controlled human trials the top of the evidence hierarchy which is why it earned an FDA approval and a real prescribing label

Drawbacks include doubled medication costs (approximately $400-600 monthly vs $200-300 for Sermorelin alone), increased side effects particularly appetite stimulation from ghrelin receptor activation, twice-daily injections reducing convenience, and complexity of managing two peptide protocols

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