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Risk Factors for Polypharmacy There are two main categories of risk factors contributing to polypharmacy: those related to patients and those associated with the healthcare system (1,4-6)

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Additionally, some MELAS patients experience loss of fixation sensitivity (FOS), an EEG phenomenon in which epileptic discharges are triggered by loss of central vision or gaze, characterized by idiopathic or generalized epileptic discharges following eye closure for more than 3 s (30)

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Doses of 400 mg daily have been safely used for up to 6 weeks in males aged 8-12 years