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This included a pattern mixture model that used comparator-based multiple imputation and AE-determined comparator based multiple imputation, as well as a tipping-point analysis (Table 21)

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Muscle loss during GLP-1 weight loss is typically linked to: Low protein intake Large calorie deficits Reduced resistance training Rapid or unstructured weight loss Weight loss always includes a mix of fat and lean mass loss, but research on GLP-1 medications suggests that while fat loss is predominant, some lean mass loss can occur depending on dietary intake and physical activity levels

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We highlight emerging evidence showing that discrete POMC neuronal subpopulations respond to specific combinations of interoceptive and environmental cues to orchestrate diverse adaptive responses