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In other words, someone who was overweight (a body mass index between 27 and 30) at the start of the study tended to see a similar reduction in heart disease risk as compared to someone with the highest level of obesity (a BMI over 40)

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Although GIP only stimulates glucagon secretion under hypo- and euglycaemic conditions in healthy individuals (57), its glucagonotropic effect is exaggerated in T2D patients during hyperglycaemia (58)

Among them, Eli Lillys Orforglipron has advanced to Phase III clinical trials, establishing itself as a frontrunner in this sector

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