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The reduced ability to conjugate glutathione may increase toxic load and oxidative stress

Common reasons for getting off a GLP-1 include: Persistent nausea, vomiting, diarrhea, constipation, or fatigue Medication costs or changes in insurance coverage Difficulty obtaining the prescribed medication Pregnancy or plans to become pregnant Reaching a personal weight goal Limited treatment response A change in health status A provider-recommended medication change A preference to manage weight without medication Why Stopping GLP-1s Causes Noticeable Changes Before discussing outcomes, it helps to understand how GLP-1 medications work and why their effects do not persist once dosing stops

Thomsen, M

Preliminary clinical studies suggest CoQ10 (300400 mg/day) improves fatigue and sleep disturbances, but larger trials are needed for confirmation