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Polyphenols are being extensively investigated in cell-based studies, animal models, human studies, and clinical trials as antidiabetic and neuroprotective agents

In addition, there was a significant nonlinear relationship between dose (2 g/day) and changes in insulin, as well as a significant linear relationship between the duration (weeks) (coefficients = 16.45, p = 0.004) of intervention and changes in HbA1C

59 Kastin and Akerstrom established in a landmark study that peripherally injected Exendin-4 passed readily through the BBB, facilitated by its lipophilicity, rather than becoming trapped in the endothelial cell

Lafeuille, M

doi: 10.1210/clinem/dgz175 88 NauckMAHeimesaatMMOrskovCHolstJJEbertRCreutzfeldtW