The GLP-1R agonists appear a promising more efficacious pharmacological treatment option for obesity given the success of liraglutide and semaglutide, and hopefully in the future clinical trials will investigate the ability of the other relevant agonists to induce weight loss in obese individuals with/without diabetes
reimbursability depends on your plan document
Specifically, it is important to consider the potential contribution of GLP-1R agonists, injected peripherally or centrally, on diuresis (21, 40), insulin secretion (18, 19, 35), blood pressure (1, 3, 8, 10, 15, 47), and visceral illness (17, 42, 44) before concluding that there is a more direct effect on water intake
Lancet 394 (10202), 939951
With insurance, those drugs cost about the same as a typical meal at a restaurant which sounds less appealing on those appetite-suppressing drugs anyway