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In addition, the GLP-1 agonists may make some drugs more aversive or unpleasant, says Luba Yammine, an associate professor of psychiatry at UTHealth Houston who is currently the principal investigator of a clinical trial evaluating a GLP-1 agonist as a potential treatment for smoking cessation and post-cessation weight management

An estimated 20% of obese patients have minimal or no response to GLP-1s and around 40% stop treatment after 12 months mostly due to shortages, dosage inconvenience3 and costs

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