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They are constantly in contact with sunlight (UV rays), food, saliva, cosmetics, and products like tobacco, all of which can affect the delicate lip tissue over time and cause pigmentation changes 4,5

Higuchi N, Kato M, Tanaka M, Miyazaki M, Takao S, Kohjima M, Kotoh K, Enjoji M, Nakamuta M, Takayanagi R (2011) Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease

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Increasing the half-life of peptides is possible by preventing their degradation by blood proteases through blocking the C- and N-termini of peptides or forming cyclically shaped peptides [29]

129 Phospholipid hydroperoxide is produced by lipoxygenase/arachidonic acid lipoxygenase-mediated peroxidation of PE phospholipids containing PUFA