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NOXs are present in most eukaryotes, including amoeba, fungi, plants, nematodes, echinoderms, urochordates, insects, fish, reptiles, and mammals 40,41

In cell-culture and ex vivo tissue models, Epithalon boosts telomerase activity, supports normal cell-cycle progression, and helps explore antioxidant defenseswithout any systemic hormone effects

Despite their significant clinical potential, they are associated with certain limitations, including suboptimal pharmacokinetics and patient adherence challenges, necessitating the development of advanced drug delivery systems to optimize efficacy and improve compliance

Acknowledgement We thank Ernesto Bernal-Mizrachi for reading the manuscript and commenting on the use of the GLP-1 mimetics in treating Type 2 diabetes

(2) AHK-Cu: Barrier repair: upregulates the expression of filaggrin and enhances the water-locking ability of the stratum corneum