discovered that SQORs active site is not a traditional cysteine disulfide, but a unique trisulfide bond linking Cys201 and Cys379 via an additional sulfur atom (Cys201SSSCys379)
What this study adds: HIIT was found to improve insulin resistance, fasting insulin, and cardiorespiratory fitness more effectively than conventional moderate-intensity continuous training, even without significant weight loss
Following the progression of the disease to CRPC or under hormonal therapy inhibiting AR function, the GLS isoform switch occurs in favor of the GAC isoform, allowing advanced PCa cells to favor Gln over glucose to sustain the TCA cycle and augmented proliferation [121]
Finally, success in clinical translation will depend on innovative delivery strategies and refined dosing paradigms (Sulong et al., 2025)
To improve gut Health & reduce inflammation Anti-inflammatory and metabolic peptides like BPC-157 support tissue repair and alleviate gut inflammation, often aggravated by hormonal shifts
