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its absence is informative but not disqualifying, especially when mechanistic and physiological evidence is otherwise robust ( Finally, insurmountable technical barrierssuch as inability to manufacture stable formulations, extreme immunogenicity, or lack of feasible delivery routesmay justify abandonment independent of biological plausibility

adjusted HR = 3.89, 95% CI: 2.455.12)

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GLP-1 receptors are present on cardiomyocytes, endocardium, microvascular endothelium, and coronary smooth muscle cells [10.0]

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