When skin is under stress (weather, over-exfoliation, lack of sleep, life), it can start looking thinner, duller, and less firm
Patients with Long COVID, ME/CFS, and dysautonomia often suffer from gastrointestinal malabsorption, genetic methylation defects (like MTHFR mutations), and impaired liver function
8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis
This was supported by another study in which liraglutide attenuated the TNF or high-glucose-mediated induction of PAI-1, ICAM-1, and VCAM-1 expression in human vascular endothelial cells, the proposed molecular mechanism underlying this effect may involve the regulation of NUR77 expression [61], which is a nuclear receptor and transcription factor involved in regulating gene expression related to cell growth, apoptosis, metabolism, and inflammation
Cell 186(22):4757-4772