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In addition to its function as an activator of type I IFN synthesis and autophagy, STING can also activate the NF-B pathway in a TBK1-IKK-dependent or TBK1-independent manner that involves DNA damage response factors ataxia telangiectasia mutated (ATM) and poly(ADP-ribose) polymerase 1 (PARP1) (146148)

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