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Accordingly, dysregulation of the FeS clusters biogenesis, including decreased expression of NFS1, has also been described as being relevant in mechanisms of resistance to cancer therapy

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The maintenance phase demonstrates whether achieved benefits persist with reduced intensity protocols or whether more aggressive approaches are necessary to sustain improvements

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2 Further research has also demonstrated that GST is expressed abundantly in tumor cells and associated closely to carcinogenesis, tumor formation, and chemotherapy resistance