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1 Department of Radiology, Helsinki University Hospital, Helsinki, Finland, 2 Folkhlsan Research Center, Helsinki, Finland, 3 Department of Neurology, Helsinki University Hospital, Helsinki, Finland, 4 Department of Radiology, Stanford University Hospital, Stanford, USA, 5 Department of Radiology, Karolinska University Hospital and Karolinska institute, Stockholm, Sweden, 6 HUS Helsinki Medical Imaging Center, Helsinki University Hospital, Helsinki, Finland, 7 Department of Nephrology, Helsinki University Hospital, Helsinki, Finland, 8 Department of Neurology, University of Gothenburg and Sahlgrenska University, Gothenburg, Sweden

doi: 10.1038/embor.2012.14 59 GudzT

The dose should be individualized based on response, tolerability, safety, nutrition, body composition, and clinical goals