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A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins
In the cell, cystine is first reduced to cysteine, and then enters the cell with the help of transporter SLC7A11 to participate in the synthesis of GSH, thus enhancing the activity of GPX4, the main antioxidant enzyme
Acknowledgments We would like to acknowledge College of Health Sciences and QU Health at Qatar University for supporting and funding this article
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