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Long-chain fatty acyl-CoA is transported into mitochondria via carnitine palmitoyl transferase 1 and 2 (CPT1 and CPT2), whereas pyruvate is taken up into mitochondria by the mitochondrial pyruvate carrier (MPC) (Noordali et al., 2018)

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The four-week minimum at each dose level allows the body to adapt to the increased GLP-1 and GIP receptor activation

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