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Increased SOD and H 2 O 2 generation, decreased nitric oxide synthesis, and impaired antioxidant bioavailability have all been associated with human hypertension (123)

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with a mean increase of 8 points) and tirzepatide (SUMMIT), appears to be greater than what has been reported for other HFpEF trials investigating the benefits of angiotensin receptorneprilysin inhibitor (Paragon-HF), sodiumglucose cotransporter 2 inhibitors (EMPEROR-Preserved, DELIVER) and spironolactone (TOPCAT)