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Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the

Severity of presentation depends on: Percentage of MetHb Rate of increase in MetHb levels The intrinsic ability of the patient to prevent or reduce MetHb The patients underlying functional status Symptoms depend on the level of MHb and its rapidity of formation, and include: 12 Dyspnea Anxiety Headache Fatigue Weakness CNS depression Dizziness Cyanosis Seizures Signs include: Cyanosis: As little as 1.5 g methemoglobin in 100 ml blood (1.5 g%) can produce clinically recognizable cyanosis

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In contrast, diets rich in fiber and low in acidity, like the Mediterranean diet, are capable of producing symptom alleviation similar to that of proton pump inhibitors [15,69]