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A review of 12 available trials found a median sample size of just 48 participants and noted that eight of the twelve studies were funded by clinics selling the injections a significant source of bias

In recent years, the development of nanoparticle-based vaccines has benefitted from advances in material science that have led to improvements in antigen structure and stability, targeted vaccine delivery, and immunogenicity with good safety profiles

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The administration of methylcobalamin, a naturally occurring form of B12, is often preferred over synthetic forms due to its superior bioavailability and potential liver support