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Levels of both enzymatic and non-enzymatic anti-oxidants are inhibited and the levels of oxidants increase in the heart, testes, liver, kidney, lung and gut tissues of laboratory animals given Amethopterin [4,6,10-16]

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Glutamine is imported into cancer cells via multiple transporters, including the Na + -dependent transporters, system ASC (alanine/serine/cysteine-preferring) that function as obligatory exchangers, and the Na + -coupled neutral amino acid transporters (SNATs), which belong to the SLC38 superfamily (Cha et al., 2018

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