Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility, University of Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award STratifying Resilience and Depression Longitudinally [STRADL] Reference 104036/Z/14/Z)
As a hallmark of UC is neutrophilic infiltration and release of pre-formed MPO-containing granules, we examined MPO protein levels by immunohistochemistry and found significantly higher MPO levels in UC patient colons than control colons (Figure 1c)
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