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Tirzepatide is a dual agonist activating GLP-1 and GIP receptors

A systematic review with meta-analysis

"All four STEP trials did not include participants who had experienced major depressive disorder in the past two years or had bipolar disorder, schizophrenia, or other significant mental illness," Wadden told Newsweek

Headache rates in SURPASS trials Across the SURPASS clinical trials, between 4% and 14% of participants reported headaches depending on the dose they received