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Antiepileptic drugs are essential for managing epilepsy but carry a risk of liver injury

While seizure types did not significantly differ between early- and late-onset LS, focal and generalized tonicclonic seizures were most common in late-onset cases (34, 36)

Peer review Peer review information Nature Reviews Cardiology thanks Aarti Asnani, Susan Dent and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

(2021) Arsenic methylation Lessons from three decades of research, Toxicology, vol

Notably, CYP27B1 is also expressed in extra-renal tissues such as the placenta and prostate, where it facilitates local synthesis of 1,25(OH)D to modulate cellular functions via paracrine or autocrine signaling [96, 99]