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Moreover, the specific dysbiosis pattern observed in women with PCOS, which was characterized by decreased Lactobacillus and increased Escherichia-Shigella, was significantly improved in the COM group of our rat model, providing direct support for our hypothesis ( 5 Conclusions In summary, our study demonstrated that the combined administration of MET and LIRA improved the metabolic and reproductive endocrine characteristics of PCOS patients, which provided some implications for guiding the clinical treatment of PCOS

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Her LLIS impairment score dropped to 26.5, half of what it was at her peak weight