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To view the full article visit: OBJECTIVE OF THE RESEARCH Sustained hyperglycemia is associated with low cellular levels of the antioxidant glutathione (GSH), which leads to tissue damage attributed to oxidative stress

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In further research, it was found that berberine achieved antioxidant effects by reducing the expression of pro-inflammatory factors, apoptotic factors and nuclear transcription factor B (NF-b), as well as up-regulating the expression of peroxlsome proliferator-activated receptor- coactlvator-1 (PGC-1) and manganese superoxide dismutase