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For Jerne this was, as he says, 'remarkable for two reasons: they are present in serum from a normal nonimmunized animal and their number increases enormously within a week after a single injection of a phage-antigen into this animal, i.e., before the serum obtains any appreciable phage-inactivating power' (Jerne, Sept 1955)

Preclinical data and practitioner observations suggest effects may occur within days

63 In this phase 1 study, no significant QTc prolongation was observed, and no severe cardiac arrhythmias, including ventricular tachycardia, were reported

In severe cases, doctors may recommend hydroxocobalamin injections for the rest of the persons life

Available from: Atkinson MA, Eisenbarth GS, Michels AW