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The underlying mechanisms include, IGF-1-induced up-regulation of the Na-Pi 2a cotransporter in the renal proximal tubules, as well as enhanced intestinal phosphate absorption, due to GH-induced increased calcitriol synthesis ( vide supra )

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Prinseq (v0.20.4) (Schmieder and Edwards, 2011) was used to filter and trim the end of the reads by quality