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Abusukhun M, Winkler MS, Phlmann S, Moerer O, Meissner K, Tampe B, et al

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Oxidative Stress and Glutathione Deficiency Biochemical changes including increased levels of neurotoxic metals, the inhibition of mitochondrial complex I activity, and depleted glutathione levels occurring in the substantia nigra 10 all suggest that oxidative stress is present and pathologically involved in PD patients

We sought to further delineate these divergent regulatory networks by investigating whether AP GIPRs modulate responses to either GLP-1R agonism or the combination of GLP-1R agonism with GIPR antagonism