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In some cases, patients on Semaglutide report fatigue or stalled results, only to later discover an underactive thyroid was the hidden culprit

Retatrutide consistently outperformed both in head-to-head comparisons

Recent reviews highlight their potential across conditions ranging from neurodegenerative diseases to musculoskeletal and cardiovascular disorders

These agents require careful dose titrations due to their adverse drug event (ADE) profile, which commonly includes nausea and vomiting

The semaglutide group also experienced: Average weight loss of 10.5% of body weight Improvements in liver enzyme levels and blood markers of liver fibrosis However, gastrointestinal side effects were more common with semaglutide, including nausea, vomiting, constipation, and diarrhea