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Moreover, TNF- disrupts the microstructure of lipid rafts on vascular endothelial cell membranes, interfering with the membrane localization and stable assembly of tight junction proteins such as ZO-1, thereby compromising intercellular sealing integrity

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This highlights the potential of combination therapy not only to improve biochemical parameters, but also to have a positive impact on patient survival and long-term health

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The following paragraphs omit the appellation predicted to enhance readability