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Frag 176-191 is thought to mimic GHs lipolytic (fat-breaking) potential while seemingly not affecting carbohydrate metabolism, insulin-like growth factor-1 (IGF-1) synthesis, or cellular proliferation

Clinical Evidence and Statistics A clinical trial 6 involving topical GHK-Cu in human volunteers (n = 40, age 4065) showed significant reductions in wrinkle volume (~31.6 %) and depth (~32.8 %) compared to vehicle control over 8 weeks

From this perspective, receptor-level signaling alone may be insufficient to ensure durable tissue-level outcomes

The significant features were selected by recursive feature elimination (RFE) methods of the training dataset