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Glutathione peroxidase 1, GPx-1, GSHPx-1, Cellular glutathione peroxidase, GPX1, GPXD, GSHPX1

However, the landmark SURMOUNT-5 trial (published in mid-2025), which compared the two medications head-to-head, clarified the clinical reality: Total Weight Loss: Tirzepatide drives significantly greater total weight loss (averaging over 20%) compared to semaglutide (averaging roughly 14%)

Never assume dizziness is 'just' medication adjustment if it's accompanied by vomiting, fever, or shortness of breath

These results project that retatrutide may have a greater efficacy than tirzepatide and semaglutide due to its triple action at GLP-1, GIP, and glucagon receptors

Youll learn how to manage side effects, support sustainable behavior change, and guide clients in building healthy habits that last beyond treatment