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Histone modifiers are also dysregulated: histone deacetylases (HDAC1-3, SIRT1), methyltransferases (EZH2, MLL1), and demethylases (LSD1) alter chromatin states, contributing to progesterone resistance, inflammation, and fibrosis

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Liraglutide, the active comparator, was initiated at 0.6 mg daily and titrated weekly up to 3.0 mg

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In tumor cells, oncogenes, tumor suppressor genes, and non-coding ncRNAs alter Gln metabolism by directly or indirectly regulating the expression and enzymatic activity of Gln-related genes