The key is gradual dose escalation, patience while steady-state levels build, and knowing that the full effect takes months to arrive
The dosing conditions are also more restricted compared to standard solid oral formulations, as food intake typically leads to dilution and degradation of biomacromolecules [14]
When used properly, GLP-1 microdosing and maintenance can help bring clarity to the process
[7,8] Beyond 6 weeks If a patient has had enough time at an effective dose with tolerable side effects and reasonable adherence, but still shows weak response, it becomes more reasonable to think about genuine low responsiveness, type 2 diabetes-related attenuation of weight-loss effect, or whether another agent may be better
doi: 10.1042/BSR20171284 213 RobinsonALubitzIAtrakchi-BaranesDLicht-MuravaAKatselPLeroithDet al