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The limitations of this work are that we included RCTs, non-RCTs, and observational studies, which may lower the overall quality of evidence of the included studies

In 3T3-L1 adipocyte cell models, 5-Amino-1MQ at 30 M concentration produced significant reductions in intracellular 1-MNA levels, confirming target engagement

Statistical analysis The data are shown as the mean and standard deviation

Physical Therapy and Exercise Appropriate movement supports healing