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doi: 10.3389/fendo.2026.1784709 Received 10 January 2026 Revised 30 January 2026 Accepted 30 January 2026 Published 18 February 2026 Volume 17 - 2026 Edited by Marcia Hiriart, Universidad Nacional Autonoma de Mexico, Mexico Reviewed by Jialin Fan, Rutgers, The State University of New Jersey, United States Kei Shing Ng, The University of Hong Kong, Hong Kong SAR, China Updates Copyright 2026 Liu, Ren, Zhang and Ma

In 1964, the development of insulin radioimmunoassay methods led to the discovery of the incretin effect, which demonstrated that oral glucose intake induces higher insulin secretion compared to intravenous (i.v.) glucose [3,4]

Researchers have found that glutathione has a positive effect on oxidative stress in lab studies

The plasmid system is relatively stable but has low cutting and editing efficiency, and continuous expression of Cas9 may increase off-target effects